Stemcelldoc's Weblog

July 31, 2011

FDA “Power Play”: Stem Cell Struggle

Stem cells are being used with increasing frequency to treatment many medical conditions.

Unfortunately the FDA has taken the position that the stem cells in your body are prescription drugs subject to regulation and control.  The Centeno-Schultz Clinic believes otherwise as we believe stem cells are body parts to be used by doctors for healing.  Accordingly we have decided to challenge the FDA’s position.  This has turned out to be a landmark case against FDA which will determine the limits of its power for years to come and ultimately decide the pace at which stem cells come into common medical use by physicians.

A local Denver magazine (5280) examined the landmark  nature of our struggle.

“Power Play: A Front Range M.D. has developed a potentially revolutionary treatment for orthopedic injuries. So why is the FDA trying to stop him?”

July 24, 2011

Day # 2: Centeno-Schultz Clinic participates in Children’s Hosptial Charity Event

Nowhere but Upward !

Day # 2 started early with memories of the  8.7 mile, 1831 foot elevation climb of Vail Pass yesterday.

0700 Day 2 Courage Classic 2011

Today was fantastic.  Rode from Copper Mountain around lake Dillon and climbed Swan Mountain Road to Sapphire Point which afforded  a stunning view of Lake Dillon and Gorge Range.  Total miles was 45.90. miles.

The Centeno-Schultz Clinic/Regenexx rode with the Gears of Courage Team who raised $243,000 in donations.

The keys to good articular cartilage have been discussed and include regular aerobic activity.  Today I achieved that goal after 4 strong hours of riding.

What an honor it is to ride for the children at the Children’s Hospital of Colorado.

Summit of Swan Mountain Road 2011

July 23, 2011

Centeno-Schultz Clinic/Regenexx Participates in Children’s Hospital Charity Event

Filed under: Uncategorized — Tags: , — stemcelldoc @ 5:21 pm

The number of childhood illnesses and treatments is endless.  Unfortunately money for treatment is finite.

The Courage Classic is a three-day,157-mile bike tour through Summit County that raises money for the Children’s Fund. In 2010, the Courage Classic raised $2.3 million, making it one of the hospital’s highest grossing events.

The Centeno-Schultz Clinic and Regenexx supports it’s community and children.  Day 1 was 58 miles and involved Vail and Tennessee Pass. The latter is a steep climb that crosses the Continental Divide.

July 2, 2011

Non Surgical Orthopedic Therapy: A Growing Trend

Treatment of common orthopedic conditions with non surgical therapy is becoming an increasing viable option among professional athletes.  Here are some examples.

Pittsburgh Steelers’ Hines Ward and Troy Polamalu underwent PRP (platelet rich plasma) injections in 2009.

Tiger Woods received PRP injections in Canada in 2010.

Superbowl Champion Jarvis Green underwent Regenexx C Regenexx SD  in 2010 and subsequently signed with the Houston Texans.

Yankees’ Bartolo Colon underwent bone marrow and adipose stem cell injections in 2011.

Kobe Bryant received PRP injections in Germany in 2011.

The Centeno-Schultz Clinic offers non-surgical treatment options for hip, knee, ankle, shoulder pain.  Treatment options include PRP (platelet rich plasma) and stem cells derived from blood (Regenexx SCP), adipose (Regenexx AD) and bone marrow (Regenexx SD).    Treatment involves the injection of prescribed regenerative agent into the damaged tissue under direct visualization utilizing either ultrasound or x-ray of both.

Dr. Allan Mishra, a professor of orthopedics at Stanford University acknowledges the potential of regenerative treatments.  “I think it’s fair to say that platelet-rich plasma has the potential to revolutionize not just sports medicine but all of orthopedics.

Elimination of surgical risks and the often extensive rehabilitation is a home run to professional athlete and weekend warriors alike.

June 29, 2011

Current Treatment of Chronic Pain is Lacking

Chronic pain is a significant problem which affects one in five patients according to the World Health Organization.

A recent article concludes that despite all the new treatments and improved understanding of the underlying pathology only 50% of the patients treated had a response to treatment and the reduction in pain was only about 30%.


Narcotics were the most commonly prescribed medication yet were associated with only small improvements in pain and were often misused.  Studies indicated that nearly 50% of long-term users may be misusing their narcotics thereby putting them at risk for overdose and death.

Regarding fusions of the lumbar spine it was noted that “High complication rates and repeat procedures are realities of spinal surgery ”

The Centeno-Schultz Clinic acknowledges the many of the main stream treatment modalities  for chronic pain are ineffective.  The Centeno-Schultz Clinic distinguishes itself by:

Publications in peer-reviewed journals.

Identifies the source of a patient’s pain as opposed to making it with oral narcotics.

Avoids  the use of NSAID’s.

Limits it use of steroids to low dose given their signficant complications including apoptosis.

Utilizes guided injections of regenerative therapies which include prolotherapy, PRP, platelet lysate(Regenexx PL), bone marrow derived and adipose derived stem cell therapy.

June 23, 2011

Successful Stem Cell Therapy for Hip Pain

Nonsurgical treatment options are becoming more prevelant and attractive.  Both surgery and anesthesia have risks.  Surgery is often followed by extensive, time-consuming painful physical rehabilitation.

CH is an 50y/o athletic patient with  2yr histoyr of left hip who was an candidate for total hip joint replacemtn.  MRI of the left hip was significant for loss of cartilage, bone spurs and bruising of the bone.   CH rejected surgery and elected to use his own mesenchymal stem cells at the Centeno-Schultz Clinic.

Treatments included Regenexx-C, Regenexx SD and myofasical deactivation

Six months post stem cell injection CH writes:  ” I believe I am about 80% healed.  Pain is greatly reduced and some days I hardly notice it at all.  One of my favorite activities prior to the arthritis was hiking and backpacking.  I have been on two hikes of 4 and 7 miles on mountain trails post treatment and did fine.  I plan to go on a backpacking trip soon as well.”

Advances in the treatment of common orthopedic conditions have allowed CH and other patients to forgo total joint replacment and return to their passions.

April 10, 2011

Centeno-Schultz Clinic: Non Surgical Regenerative Treatments

At the Centeno-Schultz Clinic a new picture is emerging.

As a pain and non surgical orthopedic clinical practice we have a large number of therapies which distinguish us from others.
Board certified physicians: Centeno, Schultz and Hanson.
Understanding the importance of function: Ortho 2.0
In office x-ray and ultrasound guided injections which ensures that the injected therapy gets to its intended target.
Acknowledging the risks and complications of traditional high does steroid injections.
A large number of regenerative therapies including prolotherapy, platelet rich plasma, platelet derived stem cell therapy(Regenexx SCP), bone marrow derived stem cell therapy(Regenexx SD) and fat derived stem cell therapy(Regenexx AD).
Treatment of chronic spinal conditions which include cervical, thoracic and lumbar facet dysfunction, foraminal and central canal narrowing due to disc protrusion or herniation and SI joint dysfunction
Non surgical treatment of common orthopedic conditions which include cartilage defects, meniscal injuries, ligamental injuries, tendonitis and tendonosis, bursitis, rotator cuff tendonopathies and muscle injuries.
Publications in peer-reviewed journals.
Strategies to maintain healthy cartilage through supplements which include Chondroitin, Glucosamine and Resveratrol.

March 13, 2011

Nutrition and Stem Cell Therapy

Is there a correlation between nutrition and osteoarthritis?


At the Centeno-Schultz Clinic and Regenexx we acknowledge the critical role between the two.

1 in 5 patients have metabolic syndrome characterized by central obesity, hypertension and elevated lipids and serum glucose. This syndrome results in the release of detrimental chemicals into the joints which can lead to the breakdown of cartilage matrix.

These same patients do poorly with knee and hip replacements due principally to the systemic proinflammatory state.

Obesity and hyperglycemia are associated with increased infection rates after knee replacements.

Diets rich in carbohydrates, refined sugar and processed food can promote a pre-diabetic state.   SIRT-1 gene expression plays an important role in circulating blood sugars levels and joint health.   Activation of SIRT-1 gene by dietary restriction and Resveratrol is associated with healthy cartilage.  Inactivation of SIRT-1 gene, commonly seen with aging and diets high in refined sugar and carbohydrates results in increased body fat, decreased energy and cartilage cells becoming less stable.  This can become the perfect storm for the onset of osteoarthritis.

In counseling deconditioned and overweight patients with osteoarthritic and musculoskeletal injuries, the Centeno-Schultz Clinic recommends at a minimum diet modification and increased activity levels.  These efforts are taken in an effort to optimize clinical outcomes from Regenexx SD, Regenexx AD and Regenexx SCP therapies.

March 3, 2011

Steroids and Cell Death: Apoptosis


Apoptosis is the process of programmed cell death.  The process is controlled by a variety of factors both within and outside of  cells.  High dose steroids have been demonstrated to create cell death in muscles, bones, cartilage and ligaments.  High dose steroids are commonly used to treat a variety of painful conditions which include rotator cuff tears, lateral epicondylitis, patellar and Achilles tendonitis, pes anersine bursitis,  lumbar facet dysfunction and sciatica.

At the Centeno-Schultz Clinic we acknowledge the negative effect of  high dose steroids.  Our aim is to identify the source of a patient’s pain and provide a therapy which will attempt to repair the damaged tissue.  Our treatments are not aimed at advancing the degenerative process or triggering apoptosis.  Accordingly we use only very small doses of steroids when necesary and have a large number of regenerative therapies which promote healing: prolotherapy, platelet rich plasma (PRP), Regenexx SCP, Regenexx AD and Regenexx SD.

February 11, 2011

Knee Pain, Micromotion and Prolotherapy

Ligaments are fibrous tissue that connect bone to bone.

In the knee there are 4 principal ligaments;  ACL(anterior cruciate ligament), PCL(posterior cruciate ligament),MCL(medial collateral ligament) and LCL(lateral collateral ligament).

Ligaments in the knee  provide structural stability for the joint.  If a ligament is injured, partially torn or stretched it affects the stability of the joint.  Instability often results in very small movements, mircomotion, within the joint that is outside the range of normal.   Micro-motion places additional forces and stress on the joint which translates to abnormal wear and tear on the joint.  Patients typically complain of instability, pain and swelling.

PR is a 40 y/o minor league baseball player who presented to the Centeno-Schultz Clinic with 10 plus year history of right knee pain who underwent multiple therapies including PT, massage, chiropractic care, Synvisc injections.  Two arthroscopic surgeries failed to provide a reduction in pain.   On physical examination his anterior cruciate ligament was noted be loose.  Not loose enough to require surgery but loose enough to create excessive wear and tear on the knee with resultant pain and swelling.

At the Centeno-Schultz Clinic, PR underwent two x-ray guided injections of prolotherapy directly into the ACL.  After the needle is placed into the ACL a small amount of contrast is injected which outlines the ligament.  This is shown below.  After two proloterapy sessions PR has had near complete resolution of his chronic knee swelling and 75% reduction in pain.  Structure stability is essential in evaluating all joints and is the standard of care at the Centeno-Schultz Clinic.


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