Stemcelldoc's Weblog

February 11, 2012

Postoperative Sternotomy Pain: New Treatment Options

At the Centeno-Schultz Clinic we acknowledge that the chronic pain following sternotomy operations can be debilitating.  Sternotomy is an incision into or through the chest bone (sternum).

Kalso followed 71 patients who had undergone thymectomy and 720 who had undergone coronary bypass grafting (CABG) and noted that  27-28% of the  patients reported chronic post-sternotomy pain.

Poststernotomy chest pain should be thoroughly evaluated to rule out serious pathology, such as infection, myocardial ischemia, and sternal  cartilage instability.

Other possible sources have been investigated by others.

Dafalque et al demonstrated entrapment of the superficial nerves by scar tissue as a cause of pain.

Weber demonstrated sternal wire sutures, either by direct sternal or periostial irritation as a cause of pain.

At the Centeno-Schultz Clinic MSK ultrasound is utilized to visualize the scar and breakup the entrapped superficial nerves.  The procedure involves the use of prolotherapy and has afforded many patients lasting pain relief.

May 26, 2009

Stem Cell Therapy for Pulmonary Hypertension

Pulmonary hypertension is serious life threatening condition characterized by an increase in blood pressure in the pulmonary artery or vein.  It is can result in shortness of breath, dizziness and fainting.  In severe cases,  patients have severely decreased exercise tolerance and heart failure.

Treatment options to date have included a large number of medication’s including calcium channel blockers, prostaglandins, endothelin receptor anatagonists and phosphodiesterase inhibitors.  Median survival rate in patients untreated is 2-3 years from time of diagnosis.  Unfortunately for those patients who have failed conventional therapy, there has been no  treatment options until recently.

Dr. Grekos reported significant clinical success utilizing adult stem cell therapy in treating pulmonary hypertension.  Dr. Grekos notes:  This is the first time medical science has successfully reversed the disease process in pulmonary hypertension, a previously untreatable condition with a very grim prognosis,”

Unfortunately such therapy may not be available if the FDA continues to exert its jurisdiction.  The FDA contends that a patient’s own stem cells are a biologic drug over which they have jurisdiction.  A physician based organization has been formed which established both clinical and laboratory guidelines for the safe use of adult stem cell therapy:


April 6, 2009

Adult Stem Cell Therapy for Chest Pain

One million patients in the United States suffer from angina:  chest pain due to blockage of the arteries in the heart.   Thirty-three percent of these patients are not afforded any benefit from traditional therapy such bypass surgery, oral medications or insertion of stents in the blocked vessels. 

Adult, autologous stem cell therapy has recently been demonstrated to be of benefit to these patients.  At Northwest University, 167 patients with severe angina underwent a prospective, randomized study in which autologous, adult stem cells were injected into the heart muscle.  Six months after the procedure, those patients who had received autologous stem cell therapy had significantly improved exercise tolerance.  These are the same patients who were not candidates for conventional therapy.

 If you are a patient and disagree with their proposed restriction of your healthcare, please visit:

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