Stemcelldoc's Weblog

September 8, 2013

Motor Vehicle Accident and Onset of Symptoms

motor vehicle injury

At the Centeno-Schultz Clinic we acknowledge the potential impact of a motor vehicle accident(MVA).  If conservative therapy fails to provide signficant and sustained  pain relief we have a variety of treatment options.

A MVA can be unsettling resulting in confusion, lack of focus, pain and restriction in range in motion.

Does onset of symptoms have significance?

Richter studied this issues in his analysis of 1176 whiplash-type neck injuries.

Richter demonstrated that complaints starting within the first 24 hours revealed no significance in regard to the duration of symptoms.

Complaints that began after more than 24 hours however lasted twice as long as the rest.

Be safe.  Focus on the road and if you are involved in an accident acknowledge that your symptoms may develop after the initial injury and that there are advanced therapies available.  You do not have to live in pain.

March 9, 2012

Use of Stem Cells in the Treatment of Non-union Bone Fractures

At the Centeno-Schultz Clinic we acknowledge that most bone fractures heal without difficulty. Unfortunately some do not.

Fractures that demonstrate motion of the bony ends and incomplete healing more than 6 months after injury are called non-union fractures.  Of the estimated 6 million bone fractures in the United States each year, approximately 10% will develop slow (delayed union) or incomplete healing (non-union).

Conservative treatments are limited and include the use of bone simulators.

Surgical options include bone grafting and or removal of existing hardware and rebreatking the the fracture with insertion of new plates and screws.  This is a significant surgery and involves extensive rehabilitation.

Stem cells are an alternative to non-union surgery.  We recently published our results.  6 patients with chronic non-union fractures were treated with treatment intervention at an average of 8.75 months post fracture.  Autologous, culture expanded stem cells were injected into the fracture through a needle utilizing intermittent x-ray.

Centeno-Schultz Clinic  continues to publish it’s clinical work in the peer-reviewed medical literature.  This clearly separates us from the majority of clinics using stem cells to treat orthopedic injuries.  Here is a link to our  publicationsthat are  indexed in the National Library of Medicine.

February 11, 2012

Stem Cell Therapy in the United States: A David & Goliath Story

The story of David and Goliath demonstrates that with righteousness on your side, one can defeat even the most enormous threats.

The battle is given in 1 Samuel,  chapter 17.   David, an Israelite and the youngest of eight sons fights a giant named Goliath.  Goliah was one of the largest and strongest Philistines.  Twice a day for 40 days Goliah challenged the Isaelites to send forth a warrior.  David steps forward with his staff and sling while Goliath is cloaked with armor and shield.  The battle ensues.

Forbes describes a 21th century David & Goliath story in their recent article:  “Stem Cells and the Lawsuit

October 9, 2011

Complications Associated with Knee Replacement

Knee replacement is increasing in frequency as means of treating symptomatic degenerative changes.

Over the last 10 years the number of partial and total knee replacements among patients 65 years and older has increased 100% ( 178,653 in 2008 to 357,472 in 2008).

Based on upon these numbers one would assume that knee replacements are safe and without  significant complication.

Unfortunately that is not the case.

Mohomed identified the following complications in patients who underwent knee replacement in 2000.

4670 cases of pneumonia

2788 pulmonary emboli.  blood clots

2908 heart attacks


Previous blogs have discussed complications associated with knee replacement surgery including wear particles, MOM and death.

Stem cell therapy is an alternative to traditional  knee orthopedic surgery.  In a peer-reviewed publication,  202 patients underwent stem cell treatment with no serious complications.  Furthermore stem cell therapy is not associated with time-consuming physical therapy and significant restrictions which can cause muscle weakness and impaired range of motion.  Regenexx is  an advanced stem cell therapy utilizing a patient’s own stem cells to treat different orthopedic knee conditions.

October 5, 2011

Regenexx-C Discussed in ESPN Magazine

Peyton Manning, Bartolo Colon and Terrell Owens all left the United States to receive orthopedic stem cell treatments.

Patients are looking for alternatives to orthopedic surgeries and joint replacements.  Many patients are fearful of the surgery and the complications.

ESPN the Magazine featured the Regenexx stem cell procedure and the treatment of NFL player Jarvis Green at the Centeno-Schultz Clinic.

August 22, 2011

Stem Cell Therapy for Hip and Knee Osteoarthritis: Presentation to Florida Academy of Pain Medicine

On August 20, 2011 Dr. Schultz presented a Stem Cell Therapy Lecture to the Florida Academy of Pain Medicine.

The lecture highlighted the clinical results of a recent study conducted at the Centeno-Schultz Clinic that examined the effectiveness of culture expanded stem cell treatments in patients with hip and knee osteoarthritis.

 148 knee patient and 54 hip patients participated in the study.  These patients sought  alternatives to knee and hip replacements.  Many of the patients were frightened by the complications associated with joint replacement surgery.

The study demonstrated that culture expanded stem cells injected into either the knee or hip-joint were associated with better improvement in pain and function when compared to untreated controls.

The different outcomes between hip and knee patients have been previously discussed on the Regenexx blog.


August 1, 2011

Is Local Anesthetic Toxic to Cartilage Cells?

Our tap water is filtered for toxic elements such as lead and mercury.

Our food is inspected and is free of toxic bacteria and harmful micro organisms.

Is the same true about common orthopedic injections?

Local anesthetics (numbing medications) are commonly used in knee and other joint injections. Typically they are used in conjunction with steroids. The two most common local anesthetics are Marcaine (Bupivacaine) and Lidocaine.

Are they toxic?

A recent study has demonstrated the Marcaine is toxic to cartilage cells.   Chu demonstrated that 6 months after a single intra-articular injection of Marcaine there was a 50% lower density of chondrocytes (cartilage cells) compared with cartilage in control joints.

What about Lidocaine?

Jacobs demonstrated that  Lidocaine was significantly more toxic to mature human articular cartilage cells than a saline 0.9% control group.

What about local anesthetics when mixed with steroids?

Farkas demonstrated the combination of glucocorticoids(steroids) and local anesthetics have an adverse effect on articular cartilage.

At the Centeno-Schultz Clinic we acknowledge the toxicity of local anesthetics and steroids.  We abandoned the use of Marcaine in our clinic three years ago.  The association of apoptosis and steroids led to our discontinuation of  high does steroids.


Please be responsible.  Don’t let friends or family members get steroid and local anesthetic injections.  There are other options available at the Centeno-Schultz Clinic.

July 31, 2011

FDA “Power Play”: Stem Cell Struggle

Stem cells are being used with increasing frequency to treatment many medical conditions.

Unfortunately the FDA has taken the position that the stem cells in your body are prescription drugs subject to regulation and control.  The Centeno-Schultz Clinic believes otherwise as we believe stem cells are body parts to be used by doctors for healing.  Accordingly we have decided to challenge the FDA’s position.  This has turned out to be a landmark case against FDA which will determine the limits of its power for years to come and ultimately decide the pace at which stem cells come into common medical use by physicians.

A local Denver magazine (5280) examined the landmark  nature of our struggle.

“Power Play: A Front Range M.D. has developed a potentially revolutionary treatment for orthopedic injuries. So why is the FDA trying to stop him?”

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