Stemcelldoc's Weblog

December 3, 2011

Orthopedic Stem Cells: How they work

At Centeno-Schultz Clinic we acknowledge the regenerative potential of stems cells in treating common orthopedic injuries.   Dr. Centeno authored a chapter on stem cell use in orthopedic injury.
Regenexx C & Regenexx SD are alternatives to knee surgeries.

How do stem cells work?

Three principal ways:  differentiation, paracrine affect and regulation of inflammation.

Mesenchymal stem cells are multipotent and can differentiate into cartilage, tendon, bone and ligament.

Paracrine means that mesenchymal stem cells release certain growth factors to assist in tissue repair.  Mesenchymal stem cells  can be viewed as construction managers as they recruit other cells to the local area and coordinate the repair of damaged tissue.  The growth factors include TGF-beta, VEGF and FGF.

Finally MSC’s have been demonstrated to regulate inflammation.  Inflammation is not all bad and is the first step in healing.


  1. Can stem cells reverse facet syndrome or reduce osteophytes prevent their regrowth after surgical removal?

    Can a biological spinal implant be made with bone implants and a disk in the middle?

    Has IDET followed by stem cells and platelet rich blood ever been done?

    Would traction or ambulatory traction be a good adjunct for injections?

    Comment by Fat Bastard — December 3, 2011 @ 10:53 pm

    • Autologous mesenchymal stem cells have been used in a limited number of patients with facet dsyfunction and pain with good clinical results. Expect more clinical discussions to be forthcoming.

      Comment by stemcelldoc — December 10, 2011 @ 4:36 pm

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